泛素蛋白酶体途径是真核生物最普遍的调控过程之一。
The ubiquitin-proteasome pathway is now considered as one of the most common regulatory processes in all eukaryotes.
目的：研究泛素蛋白酶体抑制剂对胃癌细胞增殖和凋亡的影响。
AIM: to investigate effects of ubiquitin-proteasome inhibitor on proliferation and apoptosis of gastric carcinoma cells.
泛素是一种保守的多肽单元，在泛素蛋白酶体途径中起重要作用。
Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway.
感染后肌肉肌纤蛋白基因表达下降，而肌肉泛素蛋白基因表达显著增强。
Expression of muscle myosin heavy chain-1 gene decreased and muscle ubiquitin gene expression increased in sepsis.
真核细胞使用自噬和泛素蛋白酶体系统，作为它们主要的蛋白质降解通道。
Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways.
泛素蛋白酶体途径是调节多种细胞生物学过程的重要机制，也是恶性肿瘤相关调节异常的潜在靶点；
Ubiquitin-proteasome pathway is an important mechanism regulating many processes of cellular biology, and also a potential target for abnormal regulation associated with malignancy.
目的：研究泛素蛋白质酶途径在癌性恶病质小鼠骨骼肌中的表达以及吲哚美辛(IND)对其的调控作用。
Objective: To investigate the expression of ubiquitin-proteasome pathway in skeletal muscle of cachectic mice and the effect of indomethacin (ind) on it.
p42是泛素蛋白水解酶通路中26s蛋白水解酶复合体19s帽状调节复合物的一个亚基，也是组成19s调节复合物依赖的蛋白水解酶调节子的一个组成成分。
P42 is one subunit of 19s regulatory complex of 26s proteasome in ubiquitin-proteasome pathway, and it is also one subunit of modulator, which is 19s regulatory complex dependent.
泛素是一类存在于高等生物的小分子蛋白，可结合到其他蛋白上并改变他们的基本性质。
Ubiquitin, a small protein present in cells of higher organisms, binds to other proteins and influences their fundamental properties.
第一，小泛素相关修饰，或相扑，结合其他蛋白质来改变功能或在细胞内移动它们的物理位置。
The first, Small Ubiquitin-related Modifier, or SUMO, attaches to other proteins to modify their function or physically move them within the cell (SUMOylation).
泛素在目标蛋白上形成多分子长链是多聚泛素化的开始。
Ubiquitin can form chains consisting of several molecules attached to a target protein to form polyubiquitylation.
泛素对蛋白的修饰又叫泛素化，它能极大地影响很多细胞内调控过程，该发现获得了2004年诺贝尔奖。
Modification of proteins by ubiquitin -the so-called ubiquitylation - is of greatest importance in many regulatory processes in the cell and its discovery was awarded the Nobel Prize in 2004.
我们的实验也发现，烧伤脓毒症大鼠骨骼肌内泛素系统的基因和蛋白表达显著增强。
Our study also found that the gene and protein expression of ubiquitin system in skeletal muscle were enhanced during burn sepsis.
在正常细胞中，通过组蛋白标记或DNA包装蛋白，在泛素分子的作用下，BRCA1蛋白使这些区域保持沉默。
In normal cells, the BRCA1 protein keeps these regions silent by tagging histones, or DNA packaging proteins, with a molecule called ubiquitin.
本文详细介绍了他们的发现，重点介绍了泛素调节下蛋白质降解所需要的各种物质及其机理。
The article introduce their discovery, especially the substances wanted in the course of the ubiquitin-mediated protein degradation and the mechanism.
高度保守的泛素多肽由一系列酶的作用产生并且和基质蛋白的溶解残余物相配。
The highly conserved ubiquitin polypeptide is processed by a cascade of enzymes and becomes ligated to lysine residues of substrate proteins.
在一些植物病毒和动物病毒中发现了泛素相关蛋白或泛素化病毒蛋白。
Ubiquitin-related proteins and ubiquitined vims proteins have been found in some plant viruses and animal viruses.
泛素系统是近年来新发现的一种蛋白降解途径，在机体代谢调节中起重要作用。
Ubiquitin system is a newly discovered protein degradation pathway in recent years, plays an important role in metabolism regulation.
目的分析泛素依赖的蛋白水解通路(UPP)在转染了脊髓小脑性共济失调3型(SCA3)基因的PC 12细胞中的定位及作用。
Objective To analyze the role and location of ubiquitin-dependent proteolysis pathway (UPP) in PC12 cells transfected by plasmids with spinocerebellar ataxia type 3 (SCA3) gene.
此损害导致大量多泛素化蛋白的积聚和线粒体功能障碍（被公认的细胞死亡的媒介）。
This impairment resulted in massive accumulation of polyubiquitinated proteins and of dysfunctional mitochondria which are the putative mediators of cell death.
泛素系统是近年来新发现的蛋白降解途径，目前研究认为该系统在骨骼肌蛋白高分解代谢中有重要作用。
Ubiquitin system, a new protein degradation pathway, is regarded as the important one for proteolysis of skeletal muscle.
泛素化和降解过程涉及一系列蛋白和泛素。
Ubiquitylation and degradation involve a complex set of proteins in addition to ubiquitin.
蛋白结构域分析表明，水稻泛素结合酶基因主要由一个泛素结合酶催化结构域组成。
Protein domain analysis showed that ubiquitin-conjugating enzyme genes mainly consist of a big ubiquitin-conjugating enzyme catalytic domain.
前言： 近年来，一些不依赖于转录因子活性的新型双杂交系统相继建立，如分离的泛素系统、 蛋白质片段互补分析、阻遏物重构分析和SOS恢复系统等。
Some new type of two-hybrid systems, such as split-ubiquitin system, protein-fragment complementation assay, repressor reconstitution assay and SOS recruitment system, have been developed recently.
IAA蛋白的泛素化降解在生长素反应中发挥关键性作用，ARF和AUX/IAA蛋白相互作用调节生长素响应基因的转录。
The degradation of AUX/IAA protein by ubiquitination plays essential role in auxin response, and the interaction between ARF and AUX/IAA protein regulates the transcription of auxin-response genes.
泛素/蛋白酶体系统在植物的生长发育、形态建成和抗病反应等过程中起着重要的作用。
The ubiquitin / proteasome system plays an important role in plant growth and development, morphogenesis and disease resistance.
该研究小组首次证实存在有一种蛋白质，命名为KIAA1018，该蛋白质既有泛素结合区域，还有已知的核酸酶区域。
The team first identified a protein that had both a ubiquitin-binding domain and a known nuclease domain.
泛素- 蛋白酶体途径介导的蛋白降解是机体调节细胞内蛋白水平与功能的一个重要机制。
Protein degradation mediated by ubiquitin-proteasome pathway is an important mechanism which modulates cellular proteins′ activity and function.
泛素- 蛋白酶体途径介导的蛋白降解是机体调节细胞内蛋白水平与功能的一个重要机制。
Protein degradation mediated by ubiquitin-proteasome pathway is an important mechanism which modulates cellular proteins′ activity and function.
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