结论:吗啡显著兴奋吗啡依赖大鼠腹侧苍白球神经元,腹侧苍白球在药物强化过程中起着重要作用。
Conclusi on: the firing of ventral pallidal neurons is excited prominently from morphine in the morphine dependent rats. Ventral pallidum has an important role in drug reward.
方法:通过单细胞细胞外记录吗啡依赖大鼠腹侧苍白球的电信号,观察吗啡对放电的影响。
Methods:The firing of ventral pallidal neurons in the action of morphine and naloxone was recorded and analyzed in the morphine dependent rats with extracellular single-unit recording.
方法··:毁损依赖大鼠腹侧苍白球,利用条件性位置偏爱实验测定术前、术后依赖大鼠对注射吗啡侧的偏爱程度,评价腹侧苍白球在药物强化效应程度中的作用。
Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.
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