In the rats of morphine tolerance,the levels of PWL and PWT were significant increased at 14,16 and 18 days than controls,P<0.05.
骨癌痛模型造模后14天,对照组PWL及PWT比术前降低,P<0.05;吗啡耐受组14、16、18天PWL及PWT值均高于对照组,P<0.05,第19天两组大鼠均给予小剂量的吗啡,对照组大鼠PWL及PWT值明显增加,而吗啡耐受组改善不明显。
参考来源 - 脊髓胶质细胞及前炎性细胞因子在骨癌痛中的作用及机制CCK-8s is one of the strongest endogenous anti-opioid substances and suppresses morphine tolerance which results from long term use of morphine.
CCK-8s是目前发现最强的内源性抗阿片物质,还可以降低长期应用吗啡所产生的吗啡耐受。
参考来源 - 福尔马林致痛对大鼠感觉传递通路神经元中CCK免疫反应性的影响·2,447,543篇论文数据，部分数据来源于NoteExpress
一氧化氮（NO）是与N 甲基D 天（门）冬氨酸（NM DA）受体活性相关的一种细胞内信使分子，在吗啡耐受和依赖中起作用。
Nitric oxide, an intracellular messenger molecule linked to activation of N Methyl D aspartate(NMDA) receptor, plays a role in morphine tolerance and dependence.
使用吗啡一周后，随着病人耐受其止痛效果随之降低，同时病人遭受着像成瘾和便秘的副作用。
After a week of morphine use, its effectiveness decreases as patients build tolerance, and patients also experience negative side effects like addiction and constipation.
吗啡通过作用于神经突触来缓解疼痛，但它同时也兴奋了胶质细胞，可能也加剧了该药的副作用，如嗜睡，耐受，疼痛加剧和成瘾。
Morphine deadens pain by acting at nerve synapses, but it also activates glial cells, possibly worsening the drug's side effects, such as drowsiness, tolerance, worsening of pain, and addiction.
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