双膦酸盐（bisphosphonates，BPs）是用于各类骨疾患及钙代谢性疾病的一类新药物。能特异的与骨质中的羟膦灰石结合，抑制破骨细胞活性，从而抑制骨质吸收。用于治疗骨质疏松症，变形性骨炎，恶性肿瘤骨转移引起的高钙血症和骨痛症等。
双膦酸盐有趋骨性并有抗骨质疏松症活性。
Bisphosphonate have bone? Seeking affinity, some of them are used as drugs for osteoporosis.
结论双膦酸盐对破骨细胞性骨吸收有明显的抑制作用。
Conclusions Osteoclast-mediated bone resorption was inhibited by the bisphosphonate administration.
目的评估双膦酸盐的长期应用对骨单位的次级矿化程度的影响。
Objective To evaluate the effects of long-term bisphosphoate(incardronate)administration on the mean degree of secondary mineralization in bone.
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