双膦酸盐有趋骨性并有抗骨质疏松症活性。
Bisphosphonate have bone? Seeking affinity, some of them are used as drugs for osteoporosis.
目的：为临床合理选用双膦酸盐类药物提供参考。
OBJECTIVE:To provide rational use of diphosphcmate preparations for reference.
结论双膦酸盐对破骨细胞性骨吸收有明显的抑制作用。
Conclusions Osteoclast-mediated bone resorption was inhibited by the bisphosphonate administration.
目的：研究双膦酸盐对骨形成蛋白(BMP)诱导骨的作用。
Objective To determine the effects of bisphosphonate (YM175) on the quality of bone morphogenetic protein (BMP) -induced bone.
目的评估双膦酸盐的长期应用对骨单位的次级矿化程度的影响。
Objective To evaluate the effects of long-term bisphosphoate(incardronate)administration on the mean degree of secondary mineralization in bone.
双膦酸盐类药物，抑制破骨细胞，减轻许多破坏性后果骨转移疾病。
Bisphosphonates, which inhibit osteoclasts, alleviate many of the devastating consequences of metastatic bone disease.
这一时间点后，继续双膦酸盐治疗与骨轴向力和结构完整性降低相关。
After that point, continued treatment was associated with decreased axial strength and structural integrity.
伴有肾癌骨转移患者，推荐应用双膦酸盐药物，以减少骨相关事件的发生。
Bisphosphonates is recommended for patients with bone metastases which can reduce the incidence of bone-related events.
绝经后骨质疏松症治疗中优化双膦酸盐类药物使用剂量和频率：病人的考虑。
Optimizing dosing frequencies for bisphosphonates in the management of postmenopausal osteoporosis: patient considerations.
方法：介绍双膦酸盐类药物的研究进展，对其在一些疾病中的应用进行了评价。
METHODS: to give account of research progress of diphosphonate preparations and to evaluate their application in some diseases.
目前双膦酸盐类药物治疗骨转移的主要目的是减少骨相关事件、减轻疼痛和提高生活质量。
The current aims of bi- sphosphonates for metastatic bone disease are to prevent skeletal-related events, reduce bone pain, and improve quality of life.
钙的重要性的共同药物双膦酸盐治疗骨质疏松症：一个正确的方法来提高摄入量和药物遵守。
Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence.
为进行这一试验，研究者们从23个国家招募了近2,000名没有服用过双膦酸盐类药物的患者。
For the study, researchers recruited about 2,000 patients from 23 countries who were not taking oral bisphosphonates.
结论博宁是一种安全有效的双膦酸盐制剂，与化疗联合应用可以显著缓解多发性骨髓瘤患者的骨痛。
Conclusion Bonin, as a safe and effective Bisphosphonates preparation, could relieve bone pain in multiple myeloma more effectively when combined with chemotherapy.
主要转归指标：主要分析调查了因股骨转子下骨折或股骨干骨折住院与双膦酸盐暴露时间之间的关联性。
MAIN OUTCOME MEASURES: the primary analysis examined the association between hospitalization for a subtrochanteric or femoral shaft fracture and duration of bisphosphonate exposure.
结果：BMP诱导骨3周时（即双膦酸盐未投药前），在BMP植入体周边形成编织骨，大量破骨细胞出现在新生骨组织表面。
Results By 3 weeks when bisphosphonate started to be administered, woven bones formed in the periphery of the BMP pellets.
目的：因为目前关于乳腺癌患者预防性应用双膦酸盐疗效的研究数据比较少，我们此次试验的目的就是研究乳腺癌相关性骨丢失的预防。
Purpose: Limited data are available on the efficacy of oral bisphosphonate therapy in breast cancer survivors. Our goal was to examine prevention of breast cancer-related bone loss in this cohort.
矿化程度的测定表明，低剂量和高剂量双膦酸盐组骨单位内的平均矿化程度（MDMB）都明显高于对照组，分别增加了22%和30%。
The mean degree of mineralization in bone(MDMB) in YML and YMH were significantly higher than that of CNT, and increased by 22% and 30%, respectively.
矿化程度的测定表明，低剂量和高剂量双膦酸盐组骨单位内的平均矿化程度（MDMB）都明显高于对照组，分别增加了22%和30%。
The mean degree of mineralization in bone(MDMB) in YML and YMH were significantly higher than that of CNT, and increased by 22% and 30%, respectively.
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