...经体外药物敏感实验证实,发生HBV聚合酶基因突变的病毒对 某种药物的敏感性下降,称为表型耐药;临床耐药(clinical resistance):在抗病 毒治疗过程中,由于发生耐药患者出现病毒学反弹(virologic breakthrough)和ALT 升高,称为临床耐药。
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clinical aspirin resistance 临床阿司匹林抵抗
After 240 weeks of therapy, the cumulative rates of HBV polymerase mutations, virologic resistance, and clinical resistance were 29%, 20%, and 11%, respectively.
经过240周的治疗后,HBV聚合酶的蓄聚率、病毒的耐药率和临床耐药率分别是29%,20%和11%。
In both of these clinical situations, health care staff should respond with a high level of suspicion that oseltamivir resistance has developed.
针对这两种临床病例,医务人员应该高度怀疑已产生对奥司他韦的耐药性。
OBJECTIVE: To study the common pathogenic bacteria and their drug resistance so as to provide strong evidences for clinical rational use of antibacterials.
目的:掌握我院患者常见病原菌及其耐药情况,为临床合理应用抗菌药物提供有力证据。
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