现代药理学研究表明,影响药物吸收的两个主要因素是水溶性 (aqueous solubility)和膜通透性(membrane permeability),当我们根据化合物 的理化性质来预测其膜通透性时,最主要的一个指标是脂溶性,一般来说,...
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...ywords valance connectivity index;fatty ester;fatty ketone;aqueous solubility;hydrophobic paramete; 价连接性指数;脂肪酯;脂肪酮;溶解度;疏水参数*; valance connectivity index 价连接性指数 .
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aqueous solubility SW 水溶解度SW
alkaline aqueous solubility 碱水溶解性
apparent aqueous solubility 在水中的表观溶解度
They have lots of pharmacological abilities, such as hepatoprotection and chemotherapy, but their clinical use is limited by poor aqueous solubility.
它们有很多药理活性,如肝保护、化疗辅助等,但临床应用受到了低水溶性的限制。
Aim: to formulate the spray-dried emulsion of ZLR-8, a new NO-donor nonsteroidal anti-inflammatory drug with poor absorption and sparingly aqueous solubility.
目的:对极难溶性的氮氧供体型非甾体抗炎药zlr - 8喷雾干燥乳剂进行处方研究。
Abstract: Lutein has many conjugated double bonds, which lead to poor aqueous solubility and stability and constrain its application in commercial and clinical fields heavily.
摘要:叶黄素分子中含有多个共轭双键,导致其水溶性和稳定性较差,极大地限制了其生物利用度。
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