There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate, inhibit enzyme activities and signal transduction pathways, resulting in the suppression of cell proliferation and enhancement of apoptosis, as well as the inhibition of cell invasion,angiogenesis and metastasis.
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HIF-1 plays crucial roles in oxygen homeostasis, cell energy metabolisms, tumor angiogenesis and metastasis, cell proliferation and apoptosis.
其在维持氧稳定、细胞能量代谢、肿瘤血管生成及转移、细胞增殖与凋亡等诸多方面起着重要作用。
Recently, it was found that chemokines and their receptors were involved in proliferation, angiogenesis and metastasis of various types of cancer cells.
近年来研究发现，趋化激素与其受体在癌细胞的增生、血管新生与转移上扮演重要的角色。
Vascular endothelial growth factor (VEGF) family is vital for angiogenesis and metastasis of cancer. Studies demonstrate that blockade of VEGF activity can control the growth of tumor.
血管内皮生长因子(VEGF)家族在肿瘤血管生成与转移中起关键作用，从不同途径阻断vegf的生物学作用可以达到治疗肿瘤的目的。
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