基因毒性(genotoxicity),是指污染物能直接或间接损伤细胞DNA,产生致突变和致癌作用的程度。环境中某些污染物具有基因毒性,例如,多环芳烃中的苯并芘,可致突变.使原癌基因和肿瘤抑制基因发生改变。许多化疗药物也具基因毒性,它们的不良反应是由化疗药物对正常细胞的基因毒性所致,如顺钼、卡铂、氟尿嘧啶等。
BACKGROUND:Researches at home and abroad demonstrate that silver nanoparticles can migrate and accumulate in vivo,eventually leading to cytotoxicity and genotoxicity which increases with the accumulation level.
背景:国内外研究显示,纳米银颗粒可在体内迁移、蓄积,并最终导致细胞毒性和基因毒性,且毒性可由于纳米银的蓄积而逐渐扩大。
参考来源 - 纳米银凝胶与纳米银水凝胶在模拟体液中的释放特征·2,447,543篇论文数据,部分数据来源于NoteExpress
结果:马兜铃酸具有肾毒性、消化道毒性、致癌性、致突变性和基因毒性。
RESULTS: Aristolochic acid has nephrotoxicity, alimentary canal toxicity, carcinogenicity, mutagenicity and genotoxicity.
该方法可 以应用于生物检测的许多领域,例如:核酸杂交检测、核酸损伤检测和 化学物质基因毒性的检测。
The invention can be used in biological detection, as nucleic acid cross detection, nucleic hurt detection and chemical material gene toxicity detection.
该文就细胞毒性、基因毒性、外遗传毒性这三条基本途径,对电磁辐射引起生物学效应的可能机制作一概要综述。
This thesis summarized some possible mechanisms on the biological effects of electromagnetic radiation, according to cytotoxicity, genotoxicity, epigenetic toxicity.
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