目标基因替换是基因功能分析的重要手段。
Targeted gene replacement (TGR) is an important technique for gene function analysis.
通过对影响家族成员的LRP6基因测序，科学家发现了突变导致该基因产生的蛋白其中一个氨基酸替换了。
By sequencing the LRP6 gene in affected family members, the scientists found that the mutation caused the substitution of a single amino acid in the protein the gene produced.
然而医学研究者们表示这些细胞可能会从基因水平解释疾病的起源，而且将来可能成为组织更换的来源，其可以用来替换从脊髓损伤到糖尿病等疾病中的任何病变组织。
Medical researchers, however, say the cells may reveal the genetic origins of ailments and someday serve as sources of replacement tissues in everything from spinal cord injury to diabetes.
遗传物质的多态性是基因功能调节的重要方式之一，基因编码区域单个核苷酸碱基的替换就可能改变蛋白质的结构和功能，对细胞或机体的生理功能产生重要影响。
Genetic Polymorphism is a important regulating type for the gene function, it can influence the protein structure and function by only change a single nucleotide in the coding region.
通过搭载一到一个病毒基因更正-的出租车，将提供该基因-医生将替换在修正版本与视网膜疾病的基因缺陷引起。
By piggybacking a corrected gene onto a virus - the taxicab that will deliver the gene - doctors will replace the disease-causing faulty gene in the retina with the corrected version.
核苷酸替换偏好性受其相邻碱基组成的影响现象已经在核基因组假基因序列和叶绿体基因组的非编码序列和编码序列中发现。
Influence of neighboring base composition on nucleotide substitution bias was observed in the sequence of nuclear pseudogenes and chloroplast non-coding and coding sequences.
基因治疗通常是利用病毒载体永久性地替换缺陷基因来治疗遗传性疾病。
Gene therapy is a permanent replacement of a defective gene, usually treating an inherited disorder and usually using a viral vector.
锌指核酸酶被设计识别基因组特定DNA序列，之后对其进行酶切，进而删除或替换这段序列。
Zinc-finger nucleases are enzymes that can be designed to find specific DNA sequences in the genome and cut them out, deleting those sequences or swapping one gene for another.
锌指核酸酶被设计识别基因组特定DNA序列，之后对其进行酶切，进而删除或替换这段序列。
Zinc-finger nucleases are enzymes that can be designed to find specific DNA sequences in the genome and cut them out, deleting those sequences or swapping one gene for another.
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