• In this case, it might be a piece of a virus that's replicating inside this cell.

    在这种情况下,有可能是,病毒的一部分已经开始在这些细胞中复制

    耶鲁公开课 - 生物医学工程探索课程节选

  • Make a lot of the virus, it has all of its antigenic epitopes on it, but we'll just kill it so that it can't replicate.

    先增殖出大量的病毒,病毒表面有特定的抗原决定簇,然后杀死病毒使其无法复制

    耶鲁公开课 - 生物医学工程探索课程节选

  • We've talked about killing a virus by cross-linking it, for example, to make a substance that looks like a vaccine-- looks like a virus but can't replicate.

    例如,我们谈论过,通过蛋白交联来杀死病毒,以便制造出一种类似疫苗,应该是类似病毒但却无法进行复制的物质

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  • Release of tens of thousands, hundreds of thousands of new virus particles from one individual cell such that the cell gets killed in the process of replicating the virus.

    从一个独立的细胞中,释放出数以万计甚至,数以十万记的新病毒,这会使细胞就会在,病毒复制的过程中被杀死

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  • So, one that perhaps does not reproduce in such high numbers that you create an overwhelming infection, but one that still goes through its lifecycle but is limited in its effect.

    因此,一方面这些病毒不会大量复制,从而不会导致暴发性的感染,另一方面,它依旧在进行生命周期循环,只不过对其效用进行了限制

    耶鲁公开课 - 生物医学工程探索课程节选

  • Hopefully their immune systems will respond to it like the real virus but it won't be capable of replication because we've chemically cross linked it so it can't go through its life cycle.

    人体的免疫系统,就会对该病毒产生免疫应答,但灭活的病毒不能复制,因为我们已经对它做了化学处理,使它无法进入生命周期

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, you cross link all the proteins in the virus, and you make a particle that looks like a virus but it can't act like a virus any longer because it can't replicate.

    病毒中所有的蛋白质交联后,就得到了一种看上去像病毒,却无法致病的病毒,因为这种病毒不能进行复制

    耶鲁公开课 - 生物医学工程探索课程节选

  • Or you get a cold, the cold virus takes hold, the viruses start replicating inside of you and it takes some time for immune system to gear up to eliminate it, so we're used to thinking about responses that take some time.

    或者你得了感冒,感冒病毒扎根在你的身体中,病毒开始在你体内复制,免疫系统需要一定时间做好准备去消灭它,所以我们曾认为免疫反应需要一定时间

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  • That DNA gets replicated to make many more copies of the viral DNA using host mechanisms, that is, often using the DNA polymerase which is naturally present in the host cell for its own replication.

    病毒DNA进行复制,通常是利用在宿主细胞自身的有关物质,利用宿主细胞中天然存在的,DNA聚合酶来大量复制病毒DNA

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  • Because HIV is an RNA virus and if it enters your cell the only way it can replicate, it can put its DNA into your cells, is by first making DNA out of its RNA genome.

    因为HIV是RNA病毒,如果它进入你的细胞,它复制自己的唯一方式,它能把自己的DNA转入你的细胞,方法是先用自己的,RNA基因组制造出DNA

    耶鲁公开课 - 生物医学工程探索课程节选

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