结论：地洛他定片治疗过敏性鼻炎安全、有效。
Conclusion: Desloratadine in treating allergic rhinitis is effective and safe.
前言：目的：合成地洛他定和n甲酰基地洛他定原料。
Objective: To synthesize desloratadine and its N-formyl derivative.
方法：采用LC/MS/MS（APCI源）测定地洛他定的血浆浓度，并计算药代动力学参数。
METHODS: The concentrations of desloratadine were determined by LC/MS/MS with APCI and the pharmacokinetic parameters were calculated.
地洛他定片是高效的选择性H_1受体拮抗剂，并且具有抗炎活性，可用于治疗变应性鼻炎和荨麻疹等变应性疾病。
Desloratadine, a new and selective H1-receptor antagonist with anti-inflammatory activity, was used to treat allergic diseases such as allergic rhinitis and urticaria.
地洛他定片是高效的选择性H_1受体拮抗剂，并且具有抗炎活性，可用于治疗变应性鼻炎和荨麻疹等变应性疾病。
Desloratadine, a new and selective H1-receptor antagonist with anti-inflammatory activity, was used to treat allergic diseases such as allergic rhinitis and urticaria.
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