In a separate study they found that IMRT's higher doses let 90% of early-stage patients remain cancer free for five years, up from 77% of patients treated with older methods.
Schwarz is currently compiling the data from three separate rotigotine trials--two on early stage patients and one on late-stage patients--and the company expects to file for U.S. Food and Drug Administration approval by this fall.
At a big meeting of hematologists today, Novartis unveiled data from an 846-patient trial showing that Tasigna was more effective than Gleevec in early-stage leukemia patients.
Now Glaxo is conducting giant final-stage trial in over 2000 early-stage lung cancer patients.
By contrast, Roche recently doubled the size of a trial testing a compound in patients with early-stage disease.
The foundation also contributes money to eight hospitals, including Baltimore's Johns Hopkins Hospital and Seattle's Children's Hospital, to help recruit patients for early-stage clinical trials.
And now, the drug, in combination with the chemotherapy Taxol, allows patients with early-stage breast cancer an average of four months without their disease progressing.
Ninety percent of patients with early-stage breast cancer can be cured when treated only with radiation and surgery, but another 3% also require chemotherapy to stop the cancer from spreading elsewhere.
The next step, typically, would have been to do a second-stage test (of three required phases) on a few hundred patients to confirm early results, proceeding later with costlier and bigger final-stage trials in thousands of people.
Also, 24 of 26 patients who received telaprevir in early-stage trials were cured of hepatitis C after six additional months of treatment with interferon and ribavirin.
Another early-stage trial is combining Tarceva and Avastin in colon cancer patients.
Pfizer hopes to get an early readout by the fall from its second-stage trials involving hundreds of patients.
In early-stage human trials in May 2000, scientists observed 66% fewer stomach erosions in 31 patients treated with a nitrous oxide version of a COX-2 inhibitor versus naproxen.
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