RIPs
1、核糖体失活蛋白家族(Ribosome-inactivating protein, RIPs)
可以诱导核糖体不可逆的失活的酶。
自然界主要分布在植物中,在真菌、细菌中也有发现,甚至还从一种藻类中分离得到。
RIPs通常分为两类:一类为1型核糖体失活蛋白,由一条多肽链组成,具有酶的活性;一类为2型核糖体失活蛋白,是通过二硫键连接的双链蛋白,其中A链与1型的单链类似,但B链还具有凝集素活性。
目前认为,核糖体失活蛋白是一种诱导真核细胞核糖体28S rRNA上的A4324腺嘌呤剪切,从而抑制翻译的酶。属于多核苷酸腺苷糖苷酶活性的一种。
2、REACH法令实施计划(REACH Implementation Projects)
REACH是欧盟规章《化学品注册、评估、许可和限制》(REGULATION concerning the Registration, Evaluation, Authorization and Restriction of Chemicals)的简称,是欧盟建立的,并于2007年6月1日起实施的化学品监管体系。RIPs如下:
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RIPs
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REACH Implementation Projects
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REACH实施项目
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RIP 1
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REACH Process Description: Development of a detailed description of the REACH processes
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过程描述
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RIP 2
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REACH-IT: Development of the IT system set up to support REACH implementation
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开发专用互联网系统(IUCLID国际标准化学信息数据库和REACH-IT系统)
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RIP 3
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Guidance Documents: Development of guidance documents for industry
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企业指南文件的开发 附:
1. Timelines and Obligations
2. Overview
3. Demonstrating safe use of chemicals
4. Industry contributions to RIPs
5. How Industry can Prepare for REACH
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RIP 3.1
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Registration dossier
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注册卷宗开发指南
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RIP 3.2
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Chemical safety report and SDS
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化学安全评估报告开发TGD*
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RIP 3.3
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Information Requirements on Intrinsic Properties of substances
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关于物质固有属性的信息要求
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RIP 3.4
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on Data sharing
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数据共享TGD
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RIP 3.5
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Downstream-User Requirements
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下游用户指南
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RIP 3.6
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Guidance on (C&L) under GHS
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GHS框架下分类与标记指南
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RIP 3.7
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Authorisations
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许可申请指南
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RIP 3.8
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Substances in Articles
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制成品中的物质
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RIP 3.9
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Socio-economic analyses
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SEA社会经济效益分分析开发指南
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RIP3.10
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Substance Identity
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化学物质命名与识别
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RIP 4
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Guidance Documents: Development of guidance documents for authorities
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管理当局指南文件
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RIP 4.1
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Dossier Evaluation
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卷宗评估指南
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RIP 4.2
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Substance Evaluation
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化学物质
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RIP 4.3
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Inclusion of Substances into Annex XIII (list of substances subject to Authorisation)
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附件XIV所列物质清单
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RIP 4.4
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Preparation of Annex XIV Dossiers
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附件XV卷宗筹备
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RIP 4.5
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Priority Setting for Evaluation
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评估的优评估指南
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RIP 5/6
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Setting up the Agency
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建立管理局
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RIP 7
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欧委会新增任务
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