基本信息
姓名:张春妮
性别:女
出生年月:1963年
最终学历:研究生
职称:主任技师、教授
学位:博士
职务:南京军区总医院临床检验科副主任
专业:生物化学与分子生物学、临床检验诊断学
人物履历
1984年毕业于南京大学生物系生物化学专业,获学士学位;
1987年于南京大学生物化学系获生物化学专业硕士学位;
2005年于南京大学生命科学院获生物化学与分子生物学专业博士学位;
1987-1988年,获国家卫生部笹川医学奖学金在日本熊本大学医学院生化系客座研究。
学术研究
现 从事专业:临床检验诊断学。 主要研究方向:脂蛋白与动脉粥样硬化发病机理的关系研究;微小核糖核酸作为疾病生物标志物的基础和临床研究。在国内外发表论文120多篇,以第一或通讯作 者发表SCI论文20余篇,其中多篇发表在实验诊断学领域国际著名杂志Clin Chem杂志上。
主持或参与国家“973计划”、国家自然科学基金、江苏省自然科学基金、军区医药卫生科研重点课题等基金项目。
1. 国家自然科学基金(30950100):氧化脂蛋白(a)/β2-糖蛋白I复合物作为预测血栓和动脉粥样硬化新指标的研究,负责人
2. 国家自然科学基金(81171661):血清miRNA作为恶性星形细胞肿瘤无创伤性分子标记物的筛选研究,负责人
3. 江苏省自然科学基金重点项目(BK2011013):血清microRNA作为国内高发的五种恶性肿瘤的生物标志物,负责人
4. 南京军区医药卫生科研重点课题(12Z28):血清中的脑特异性微小核糖核酸对脑外伤监控和预后价值及研究,负责人
5. 南京军区医药卫生科研基金(07M088):血清免疫球蛋白游离轻链浓度检测方法的建立和临床应用研究,负责人
学术兼职
南京市医学会检验分会副主任委员
中国人民解放军医学科学技术委员会生物技术专业委员会委员
江苏省医学会检验分会委员
授权专利
以第一发明人获得两项授权的国家发明专利:
1. 一种肝素亲和柱及其制备方法和应用,2010年授权
2. 一种用于检测食管鳞状细胞癌的微小核糖核酸组合及其应用,2013年授权
代表性论文
1.LuoY,Wang C, Chen X, Zhong T, Cai X, Chen S, Shi Y, Hu J, Guan X, Xia Z, Wang J, ZenK, CY,Zhang C*. Increased serum and urinary microRNAs in children with idiopathicnephrotic syndrome. Clin Chem, 2013,59(4):658-666
2.Yang C, Wang C, Chen X, Chen S, Zhang Y, Zhi F, WangJ, Li L, Zhou X, Li N, Pan H, Zhang J, Zen K, Zhang CY, Zhang C*. Identification of seven serummicroRNAs from a genome-wide serum microRNA expression profile as potentialnoninvasive biomarkers for malignant astrocytomas.Int J Cancer, 2013,132(1): 116-127
3.Wang C, Yang C, Chen X, YaoB, Yang C, Zhu C, Li L, Wang J, Li X, Shao Y, Liu Y, Ji J, Zhang J, Zen K,Zhang CY, Zhang C*. Alteredprofile of seminal plasma microRNAs in the molecular diagnosis of maleinfertility. Clin Chem,2011, 57(12):1722-1731
4. Zhang C*, Wang C, Chen X,Yang C, Li K, Wang J, Dai J, Hu Z, Zhou X, Chen L, Zhang Y, Li Y, Qiu H, XingJ, Liang Z, Ren B, Yang C, Zen K, Zhang CY, Expression profile of microRNAs inserum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem, 2010, 56(12):1871-1879
5.Chen X, Hu Z, Wang W, Ba Y, Ma L,Zhang C (co-first), Wang C, Ren Z, Zhao Y, Wu S, Zhuang R, Zhang Y, HuH, Liu C, Xu L, Wang J, Shen H, Zhang J, Zen K, Zhang CY, Identification of ten serum microRNAsfrom a genome-wide serum microRNA expression profile as novel noninvasivebiomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer, 2012, 130(7):1620-1628
6.Liu R, Zhang C(co-first), Hu Z, Li G, Wang C, Yang C, Huang D, Chen X, ZhangH, Zhuang R, Deng T, Liu H, Yin J, Wang S, Zen K, Ba Y, Zhang CY, A five-microRNA signature identifiedfrom genome-wide serum microRNA expression profiling serves as a fingerprintfor gastric cancer diagnosis. EurJ Cancer, 2011,47(5):784-891
7.Wang C, Niu DM, Hu J, Guan XC,Yang W, Wang JJ,Zhang CY, Zhang C*. Elevated serum β2-glycoprotein-I-lipoprotein(a)complexes levels are associated with the presence and complications in type 2diabetes mellitus. Diabets Res Clin PR, 2013,100: 250-256
8.Zhang C, Luo Y, Huang Z, Xia Z, Cai X, Yang Y, Niu D, Wang J. Elevated serum β2-GPI-Lp(a)complexes levels in children with nephrotic syndrome, Clin Chim Acta, 2012,413 (19-20):1657-1660
9.Wang J, Gong J, Li H, Niu D, Han A, Wu J, Zhang C*. Lipoprotein(a) complexes withbeta2-glycoprotein I in patients with coronary artery disease. J Atheroscler Thromb, 2012, 19(1):81-89
10.Zhang C, Li X, Niu D, Zi R, Wang C, Han A, Wang X, Li K, WangJ, Increasedserum levels of β2-GPI-Lp(a)complexes and their association with premature atherosclerosis in patients withrheumatoid arthritis. ClinChim Acta, 2011, 412(15-16):1332-1336
11.Zhang C, Li X, Niu D, Zi R, Wang C, Han A, Wang X, Li K, Wang J. Increased serum levels of complexesand their association with premature atherosclerosis in patients of rheumatoidarthritis. Clin Chim Acta, 2010;412:1332-1336
12.ZhangC, Li K, Shi B, Wang X, Liu X, Qin W, Han A, WangJ. Detection of serum β2-GPI–Lp(a) complexes in patients with systemiclupus erythematosus. Clin Chim Acta, 2010; 411(5-6): 395-399
13.Wang J, Niu D, Meng Y, Han A, Li K, Zhang C*. Plasma oxidized lipoprotein(a) and itsimmune complexes are present in newborns and children. Clin Chim Acta, 2009;407(1-2): 1-5
14.WangJ, Zhang C (co-first),Meng Y, Han A, Gong J, Li K. Elevated concentrations of oxidized lipoprotein(a)are associated with the presence and severity of acute coronary syndromes. Clin Chim Acta, 2009; 408(1-2): 79-82
15.Zhang C, Niu D, Li K,Yang Y, Liu X, Zhuang Y, Zhang H, Wang J.Referencevalues for serum levels of cholesteryl ester transfer protein and itsdistribution characteristics in healthy Chinese children and newborns. ClinBiochem, 2008;41 (13): 1107-1109
16.WangJ, Hu B, Kong L, Cai H, Zhang C*. Native, oxidized lipoprotein(a)and lipoprotein(a) immune complex in patients with active and inactiverheumatoid arthritis: Plasma concentrations and relationship to inflammation. Clin Chim Acta, 2008;390 (1-2): 67-71
17.WangJ, Zhang C*, Gong J, Zhu Y, Fu L,Wang X, Li K.Development of new enzyme-linkedimmunosorbent assay for oxidized lipoprotein(a) by using purified humanoxidized lipoprotein(a) autoantibodies as capture antibody. Clin Chim Acta, 2007;385 (1-2): 73-78
18.Zhang C, Yao M, Wang X,Zhuang Y, Xia Z, Yang Y, Li Y, Liu X, Li K, Wang J.Effectof hypoalbuminemia on the increased serum cholesteryl ester transfer proteinconcentration in children with idiopathic nephrotic syndrome. ClinBiochem,2007;40 (12): 869-875
19.Wang,J., Gu Q, Li, K, Zhang C*. CETP andoxidized LDL levels increase in dyslipidernic subjects. Clin Biochem,2007;40(13-14): 995-999