...个结合位点考察其合理性,并在此基础上研究复方分子成分数据库与靶点A5LOX间作用效应,以具显著抑制该靶酶活性的齐留通(Zileuton)作为阳性对照,以其筛选得分作为阈值,并进行方法学考察。
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CONCLUSION: 5-LOX inhibitor caffeic acid protects the neurons against the injury 24 after focal cerebral ischemia in rats. 5-LOX inhibitors (caffeic acid and zileuton) protect PC12 cells against OGD-induced ischemic-like injury.
结论:5-LOX抑制剂咖啡酸能减轻脑缺血/再灌注后神经元的损伤;5-LOX抑制剂咖啡酸和齐留通均可减轻缺糖缺氧诱导的PC12细胞缺血样损伤。
参考来源 - 5·2,447,543篇论文数据,部分数据来源于NoteExpress
目的:合成抗哮喘新药齐留通。
Objective: to synthesize a novel anti-asthmatic drug zileuton.
方法:以2-乙酰基苯并噻吩为起始原料,经3步反应合成齐留通。
Methods:Zileuton wassynthesized via 3-step reactions with 2-acetyl benzothiophene as the starting material.
目的探讨齐留通阻断5 -脂氧合酶(5 - LOX)代谢途径对胰腺癌细胞增殖和凋亡的影响。
Objective to probe into the effect of zileuton, a special inhibitor of 5-lipoxygenase (5-lox), on the proliferation and apoptosis of pancreatic cancer cells in vitro.
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