Bisphosphonates are analogues of pyrophosphate. They can inhibit osteoclast-mediated resorption of bone, decrease bone turnover by inhibiting the recruitment of osteoclast and differentiation of osteoclast precursors.
双磷酸盐是无机焦磷酸盐的类似物，它主要通过抑制破骨细胞的募集和破骨前体细胞的分化成熟，从而抑制骨吸收，降低骨转换，在骨计量学上表现为降低小梁骨的“吸收深度”和“刺激频率”，因而能减少“穿孔”吸收的发生，保护骨的的显微结构。
参考来源 - 氟，羟乙磷酸钠和1，25双羟维生素D·2,447,543篇论文数据，部分数据来源于NoteExpress
种植术后第4、12周分2批处死动物，制作不脱钙标本切片，形态学观察及骨计量学检测。
Animals were killed at 4 and 12 weeks after implantation surgery and undecalcified sections were prepared and examined histologically and histomorphometrically.
氟，羟乙磷酸钠和1,25双羟维生素d_3干预对去卵巢大鼠骨的骨计量学和生物力学性质的影响。
Effects of Fluoride, Etidronate and 1, 25-dihydroxyvitamin D_3 Intervention on the Histomorphometry and Biomechanical Properties of Bone in Ovariectomized Rats.
分期植入动物股骨内，取不同期骨标本制备磨片，用骨计量学方法分析比较不同种植体界面骨的生长代谢情况，从定量、动态的角度对其生物相容性给予评价。
Histomorphometry was used to analyse and compare bone growth metabolism of bone interface with implant as well as evaluation of biocompatibility from quantitative and dynamic aspects.
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