One of the most serious clinical manifestations of chronic fluorosis is skeletal fluorosis. The pathological manifestation of skeletal fluorosis has diversity, including osteosclerosis, osteomalacia, osteoporosis and bone degenerative cartilage.
氟骨症是慢性氟中毒最主要也是最严重的临床表现,其病理表现多种多样,其骨损害包括骨硬化、骨软化、骨质疏松、骨周软组织化骨以及软骨和关节的退行性改变。
参考来源 - 高氟暴露对人群血清OPG、RANKL及OPG/RANKL影响的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
作者使用骨髓移植治疗一个6个月大的有恶性的婴儿骨硬化病的男孩。
The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation.
主要X线与CT表现为溶骨性骨质破坏，偏心膨胀性生长，粗细不均的骨性间隔，边缘增生硬化及骨化。
The main appearances of the X-ray and ct were osteolytic bony destruction, eccentric and expansive growth uneven bony septations, and rim osteosclerosis and ossification.
骨上皮样血管内皮瘤的特征性表现是多灶性的溶骨性病变伴随骨膨胀、硬化边，不伴有骨膜炎。
The characteristic appearance of an osseous epithelioid hemangioendothelioma is a multifocal lytic abnormality with osseous expansion, sclerotic margins, and a lack of periostitis.
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