突变小鼠的颅底软骨发育障碍导致颅底骨组织的生长发育也出现障碍。
All these developmental disorder in cranial base of mutant mice resulted in the disturbance of tissue growth of cranial base.
粘多糖在骨组织沉积可致成骨发育障碍和变形，在关节沉积可引起关节硬化；
Deposition of mucopolysaccharides in bone tissue causes disorder in bone development and deformation of bone; in joint causes hardened joint;
可能为胚胎期基因缺陷致骨骺生长层发育障碍。
Gene defect during embryonic period may interfere the growth of osteoepiphysis.
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