结论染料木黄酮首过代谢突出，血浆中药物主要以葡糖醛酸结合形式存在。
Conclusion Due to significant first pass metabolism, the drug was mainly existed in the form of glucuronidated genistein in the plasma.
鼻腔给药具有吸收迅速、避免首过代谢等优点，在近年来已引起广泛关注。
Drug delivery through the nasal route has received a lot of attention recently because of its advantages such as rapid absorption, avoidance of first-pass elimination and so on.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
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