国际呼吸杂志092014 关键词： 切除修复交叉互补基因1;生存素;顺铂耐药 [gap=755]Keywords ：Excision repair cross-complementing 1;Survivin;Cisplatin resistance
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主题：癌细胞 | 医源世界 关键词】 切除修复交叉互补基因1;金属硫蛋白1H;顺铂耐药 [gap=1502]Key words】 ERCC1;MT1H;drug resistance to cisplatin
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Trichostatin A Induced Bcl-2 Protein Level Decrease Mediated A549/CDDP Cells Apoptosis by Mitochondria Pathway | WU | 中国肺癌杂志 关键词 】曲古抑素A；顺铂耐药；细胞周期；细胞凋亡；线粒体膜电位；Bcl-2 [gap=2223]Key words 】Trichostatin A; Cisplatin-resistance; Cell cycle; Apoptosis; Mitochondrial membrane potential; Bcl-2
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Aim To induce cisplatin-resistant esophageal squamous carcinoma cell line and investigate the mechanisms by which the cancer cells develop drug resistance.
目的诱导对顺铂耐药的人食管鳞癌细胞株,并进一步研究细胞耐药性产生的机制。
参考来源 - 顺铂降低铜离子转运蛋白1表达诱导人食管鳞癌细胞耐药·2,447,543篇论文数据，部分数据来源于NoteExpress
当PIDD水平在肺癌细胞人为增加时，它们对顺铂耐药性增强。
When PIDD levels are artificially increased in human lung cancer cells, they become more resistant to cisplatin.
目的：建立人卵巢癌顺铂耐药细胞株COC1/DDP，探讨其耐药的机制。
Objective: To establish a cisplatin-resistant ovarian cancer cell line COC1/DDP, and investigate the mechanism of resistance.
顺铂的主要药理机制是损伤细胞DNA，肿瘤细胞DNA修复能力增强则会导致其对顺铂耐药。
The main mechanism of cisplatin is tumor cells death by damaging the DNA. The resistance to cisplatin is associated with the cell's increased ability of DNA repair.
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