由一分子长链脂肪酸、一分子鞘氨醇或其衍生物及一分子极性头醇组成。鞘氨醇是鞘脂中许多长链氨基醇的母体化合物,在哺乳动物中较丰富。鞘脂的极性头基与鞘氨醇的羟基结合,而脂肪酸部分则与其氨基形成酰胺键。
嗜热菌杀酵母素通过耗尽细胞的鞘脂类诱导凋亡,抑制白介素2依赖性的小鼠毒性细胞的增殖,是一种有效的免疫抑制剂。
Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.
神经酰胺作为神经鞘脂类的主要成员之一,是一个主要调节细胞活动的第二信使,以转导细胞凋亡等细胞生长抑制活动信号为主。
Ceramide as an important member of sphingolipid is a second messenger responsible for regulating cellular activities, whose major function is to transmit growth-inhibiting signals including apoptotic.
神经鞘脂病是一类神经鞘脂分解代谢障碍的遗传性疾病,酶学检测是确诊的一种主要手段。
Sphingolipidosis is a group of hereditary diseases characterised by the deficiency in enzymes responsible for catabolism of sphingolipids.
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