探究暗能量的本质是自然科学最大的难题之一。
Understanding the nature of dark energy is one of the biggest problems in science.
生命起源问题是科学上最悬而未决的难题之一。
The origin of life is one of the great unsolved problems of science.
编辑器开发似乎是计算中最棘手的难题之一，而且很少能找到帮助。
Editor development seems to be one of the trickiest problems in computing, and every little bit helps.
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