The down-regulation of keratin 13 and keratin 1 in POP vaginal tissue suggest that the differentiation of vaginal epithelium is suppressed. It results in vaginal epithelium becoming thin and affects the supporting role of vaginal wall.
2、角蛋白13和角蛋白1在POP患者阴道组织中表达显著下调提示POP患者阴道上皮层的分化受抑制,导致阴道上皮层变薄,影响阴道壁的支撑作用,因而易发生POP。
参考来源 - 盆腔器官脱垂患者及对照者阴道组织蛋白质组的比较研究·2,447,543篇论文数据，部分数据来源于NoteExpress
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