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钙拮抗剂硝苯啶与钾通道开放剂米诺地尔均能抑制4 - AP诱发的小鼠舔体反应，且给4 - AP部位，皮肤组胺含量明显高于对照组。
Nifedipine, a calcium antagonist, and minoxidil, a potassium opener, could inhibit the licking response and prevent the decrease of histamine content in the skin induced by 4-ap.
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