他们怀疑如果患者在社交生活中没有得到重大的改善，那么即使痤疮在治疗之后得以好转，他们仍然可能精神沮丧。
They suspected patients whose acne improved after treatment might still be depressed if there were no major improvements in their social lives.
另外她还需要详细阐述她的主要政策纲领，包括像税收或环境变化这样重大的议题，而且有人怀疑她有过度干涉的倾向。
She has yet to spell out much of her policy platform, including on such vital issues as tax or climate change; and has suspiciously meddlesome tendencies.
怀疑论者表示，这些机器不能代表超越视频会议的重大进步。
Skeptics say these machines do not represent a great improvement over video teleconferencing.
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