方法采用反相高效液相色谱法检测5-脂氧合酶产物——白三烯B4和5-羟花生四烯酸量的变化来反映该酶活性的改变。

Methods 5- LO products, leukotriene B4 (LTB4) and 5 hydroxyeicosatetraenoic(5-HETE), we re determined by RP-HPLC to represent 5-LO activity.

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花生四烯酸代谢产物白三烯B_4与炎症及过敏反应中白细胞的各种活动密切相关。筛选有效的白三烯B_4抑制荆可为临床提供抗炎抗过敏反应的一代新药。

LTB4 is one of the metabolites of arachidonic acid via 5-Hpoxygenase pathway. lt is a potent inflammatory mediator and is related to actions of leukocytes in hypersensitive reactions.

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