本文就小分子酪氨酸激酶抑制剂治疗非小细胞肺癌脑转移的机理、临床应用以及治疗失败后的处理等方面作一综述。
The mechanisms, clinical applications of small-molecule tyrosine kinase inhibitors on brain metastasis and therapeutic choice after the failure will be reviewed in this article.
随着小分子酪氨酸激酶抑制剂在非小细胞肺癌治疗上获得成功，陆续有其治疗非小细胞肺癌脑转移及脑膜转移的研究。
With the success of small-molecule tyrosine kinase inhibitors in non-small cell lung cancer, recent clinical researches have shown their activities against brain and leptomeningeal metastases.
摘要：目的 研究酪氨酸硫化修饰对酪氨酸硫化转移酶（TPST）1和TPST 2的调节作用。
ABSTRACT:Objective To investigate the role of sulfated tyrosine in regulating the activity of tyrosylprotein sulfotransferases (TPST) 1 and TPST2.
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