CYP450的合成受着遗传基因的调控，一旦基因发生变异，它所调控合成的CYP450酶及酶所催化的药物代谢即发生变化。
CYP450 is regulated by genetic genes. Once the gene mutates, the CYP450 enzyme that coded and the drug metabolism then will change.
目的：探索家族性2型糖尿病的遗传方式及家族性2型糖尿病家系一级亲属正常糖耐量同胞的血糖血脂代谢变化。
Objective:To investigate the inheritance mode of familial type 2 diabetes and to study the changes of blood glucose and lipid levels in normal siblings.
遗传因素中包括细胞增殖因子、转录因子及影响叶酸代谢的关键酶的基因。
The genetic factors include cell growth factors, transformation factors and key enzymic genes involved in folate metabolism.
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