P65 is a neural-specific protein and binds directly to syntaxin, synapotic membrane protein, to form a complex that regulates neurotransmitter release by mediating the docking and fusion of synaptic vesicles to presynaptic membranes.
P65是一种神经特异性蛋白,可与突触膜蛋白Syntaxin直接结合,并形成复合物,通过调节突触小泡与突触前膜的锚定、融合过程,实现其对神经递质释放的调节。
参考来源 - PAK4与P65相互作用的证实·2,447,543篇论文数据,部分数据来源于NoteExpress
一般来说,动作电位到达突触节会导致神经递质释放到突触间隙。
In general, action potentials that reach the synaptic knobs cause a neurotransmitter to be released into the synaptic cleft.
目的观察低温对沙土鼠单侧脑缺血时氨基酸递质释放的影响。
Objective To observe the effect of hypothermia on amino acid release in ischemic side of brain in gerbils.
目的了解依托咪酯是否通过抑制突触前神经递质释放而影响中枢突触传递的。
Purpose to identify whether etomidate could depress KCl-induced neurotransmitters release from nerve terminals, which underlie central synaptic transmission inhabitation.
But in general, for each neurotransmitter that released it there would only be one population of receptors that's ready to receive it.
但总体说,每一种在此释放的神经递质,只能被一类受体接受
Then, there are antagonists that slow down the amount of neurotransmitters, either because they destroy neurotransmitters or they make it hard to create more.
另一种是抑制剂,抑制剂会抑制神经递质的释放量,有可能是通过破坏神经递质而实现,也可能是通过抑制神经递质的生成而实现
This process, which is shown schematically here, as a vesicle fusing with the cell membrane and then dropping its neurotransmitter only happens when an action potential reaches the end of the axon.
这一过程 扼要地展示在这里,小泡同细胞膜融合,释放其神经递质,这只发生在动作电位抵达轴突末梢时
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