世界卫生组织报告称，从治疗总费用和生产力损失来看，抑郁症是世界上产生的负担最重的疾病。
The World Health Organization reports that depression has the greatest burden of disease worldwide, in terms of the total cost of treatment and the loss of productivity.
面对任何一个自然或人为的紧急情况，我们的首要目标是减少不必要的生命损失，以及减轻疾病和伤残所带来的负担。
The primary objective in an emergency, whether natural or man-made, is to reduce avoidable loss of life and the burden of disease and disability.
费雪强调因通缩而蒙受损失的借款人缺的主要是现金，一旦债务负担上升则将迫使他们急剧地削减开支。
Fisher argued that borrowers, who lose from deflation, are typically short of cash and will be forced to cut their spending sharply when their debt burden rises.
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