表阿霉素属于抗生素类抗肿瘤药。为阿霉素的同分异构体，作用机制是直接嵌入DNA核碱对之间，干扰转录过程，阻止mRNA的形成，从而抑制DNA和RNA的合成。此外，表阿霉素对拓朴异构酶Ⅱ也有抑制作用。为一细胞周期非特异性药物，对多种移植性肿瘤均有效。与阿霉素相比，疗效相等或略高，但对心脏的毒性较小。
n. epirubicin
misc. pharmorubicin
Objective To investigate the inhibition of 7 human cancer cell lines by resveratrol and epirubicin treated in combination. Methods Tumor cell lines were cultured in vitro,treated with resveratrol and epirubicin in combination for 24 hours.
目的探讨白藜芦醇与表阿霉素联合用药对7种人类肿瘤细胞的体外抑制作用。
参考来源 - 白藜芦醇与表阿霉素联合用药对多种人类肿瘤细胞的体外抑制作用Additionally, we also observed that sensibility to pharmorubicin inMCF-7 expressing BCRP could be enhanced by TAM (P＜0.001).
此外尚观察到TAM使表达BCRP的MCF-7细胞对表阿霉素的敏感性增加(P＜0.001)。
参考来源 - 三苯氧胺逆转过表达BCRP的JAR/VP16细胞对VP16耐药性的研究Study showed that over-expression IMMT could effectively inhibit Tim23 degradation under Epirubicin , and retard the process of apoptosis.
研究发现,过表达IMMT可以有效地抑制表阿霉素作用下Tim23的降解,延缓细胞凋亡进程。
参考来源 - 基于线粒体膜间隙蛋白质相互作用网络的基因功能研究·2,447,543篇论文数据，部分数据来源于NoteExpress
陶蔚目的研究表阿霉素在大鼠胰腺和血液中的分布规律。
Objective To study the distribution of epirubicin in blood and pancreatic tissue of rats.
目的探讨白藜芦醇与表阿霉素联合用药对7种人类肿瘤细胞的抑制作用。
Objective To investigate the inhibition of 7 human cancer cell lines by resveratrol and epirubicin treated in combination.
目的：制备盐酸表阿霉素脂质体，建立HPLC含量测定方法并优选包封率测定方法。
Objectives: To prepare epirubicin hydrochloride liposomes(Epi-lip), establish an HPLC method for the determination of EPI and to optimize the method for determination of entrapment efficiency(EE%).
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