能明显抑制小鼠毛细血管通透性增高和棉球肉芽肿形成。
It can reduce capillary permeability and granuloma formation in mice.
结论体外循环可诱导炎症反应致内皮细胞损伤或激活，并可致血管通透性增高。
Conclusion CPB can induce activation damage of vascular endothelial cell, and increase vascular permeability.
S1P能改善PAF引起的血管通透性增高，其作用与加强内皮细胞间粘附连接，抑制细胞间隙打开有关。
S1P improves the increase in the microvessel permeability caused by PAF, which might be mediated by strengthening adherent junction and inhibiting the formation of endothelial gaps.
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