主要是指膜结合核糖体上合成的蛋白质, 通过信号肽,在翻译的同时进入内质网, 然后经过各种加工和修饰,使不同去向的蛋白质带上不同的标记, 最后经过高尔基体反面网络进行分选,包装到不同类型的小泡,并运送到目的地, 包括内质网、高尔基体、溶酶体、细胞质膜、细胞外和核膜等。广义的蛋白质分选也包括在游离核糖体上合成的蛋白质的定位。
特别地,在非蛋白质编码部分选择如何工作,选择丢弃什么样的变异:少数常见基因影响小或者许多罕见基因影响大?
In particular, how does it work on the non-protein-coding parts, and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
特别地,在非蛋白质编码部分选择如何工作,选择丢弃什么样的变异:少数常见基因影响小或者许多罕见基因影响大?
In particular how does it work on the non-protein-coding parts and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
目前上皮细胞蛋白分选和蛋白质之间相互作用开始被逐渐阐明。
The nature of this information, and of the protein-protein interactions involved in its interpretation, is beginning to be elucidated.
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