Strain stability and polarity of bioactive compounds were investigated to deal with 5 strains with good antimicrobial activity. . And strain Hp-109 was selected as target strain depending on it's good antibacterial activity, good stability and polarity.
以菌株稳定性、活性物质稳定性和极性为主要标准，对具有初步活性的相关菌株进行了考察，获得一株目标菌株Hp-109。
参考来源 - 繁茂膜海绵放线菌活性筛选、诱导的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
试验结果表明，其发酵单位大幅度提高，较出发菌株提高了8.9%，并且其遗传稳定性较好。
The results show that its fermentation unit is increased by 8.9% than the starting strain, and its genetic stability is good, too.
同时通过对高产菌株进行传代培养检验其传代稳定性，结果表明，传代3代后，菌株开始退化，并且其发酵效价有比较显著的下降。
The stability of the high-yielding mutant was tested, the result showed that after passing 3 generations, the strain began to retrogress and the total titer had a substantial decline.
经6次传代培养后，其生物量和菌丝多糖产量较稳定，且明显超过原始菌株，表明其遗传稳定性良好。
After continuous cultivation for 6 generations, the biology yield and the polysaccharide yield were steady and obviously exceeded the original strain. It showed a good genetic stability.
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