顺铂通常第一次给药时有效，它有一个主要的缺陷：肿瘤获得耐药性，而且重新开始生长。

While cisplatin is often effective when first given, it has a major drawback: Tumors can become resistant to the drug and start growing again.

youdao

为了找出原因，研究员分析了那种基因在获得耐药性是转录的最多，辨别几种参与了DNA修复途径。

To figure out why, the researchers analyzed which genes were being transcribed more as resistance developed, and identified several that are involved in DNA repair pathways.

youdao

抗菌素耐药性指微生物对原本有效的抗菌素产生耐药性，当微生物发生突变或获得耐药基因时，就产生了耐药性。

Antibiotic resistance to originally effective means microbes antibiotic resistance mutations or, when microbes get resistance genes, it showed resistance.

youdao