有毒植物中包含各种具有生物活性多样的化合物和结构复杂的次生代谢物，是寻找抗肿瘤药物的丰富资源。
Plants are known to possess many different components or secondary metabolites which have various biological activities, including anticancer.
对于那些生成活性代谢物的药物来讲，经过首过代谢的治疗上的重要性取决于药物和代谢物所引起的期望的和非期望的效应。
For drugs with an active metabolite, the therapeutic consequence of first-pass metabolism depends on the contributions of the drug and the metabolite to the desired and undesired effects.
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