肾脏疾病对高原型排泄分数药物的代谢动力学影响较大。
Renal diseases produce greater effects on the kinetics of drugs with a high fraction excreted unchanged.
肠道微生物群落对健康具有特别重要的意义，它们可以影响食物和药物的代谢。
The microbial communities of the gut, in particular, have important implications for health by affecting metabolism of food and drugs.
药物的代谢和清除存在差异且当他们像这样相互时，就不良反应而言可能会出现可怕的问题。
There are differences in drug metabolism, differences in drug clearances and when they interact like that you can have frightening problems in terms of adverse reactions.
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