(2)舌下给药:药物通过舌下给药(sublingual administration)经口腔黏膜吸收直接进入血液循环,可避免首过消除。
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结论渗透促进剂可以不同程度地影响膜脂流动性和膜蛋白构象,提高胰岛素经舌下给药后的降糖效果。
CONCLUSION Penetration enhancers can change the fluidity of membrane lipid and the conformation of membrane protein in certain degrees, and increase the sublingual absorption of insulin.
把一种药物置于齿龈和面颊之间(颊部给药)或置于舌下(舌下给药)则可保留较长时间,使吸收更加完全。
A drug placed between the gums and cheek (buccal administration) or under the tongue (sublingual administration) is retained longer so that absorption is more complete.
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