段誉吓得几欲晕去，但觉咽喉、食道自上向下的麻痒落去，蜈蚣已钻入了他肚中。

A greatly frightened Kudus almost fainted. An itchy sensation went down his digestive track and the vermin had gone into his stomach.

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但是传统的青少年社区服务是以单位制、计划经济而构建的，是一种自上向下的帮助。

However, the traditional youth community service system is built according to the planned economy, so it is a top-down help.

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采用自上向下的模块化设计方法，将PDDC的功能划分为基本单元，实现这些功能模块并组成模块库。

Using Top-Down design method, the whole PDDC function is divided to many units implemented respectively and organized to the module library.

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This is important because this molecule here, deoxyribose, is not the same upside down as it is - it's not symmetrical upside down and right side up, it's different because the 5' carbon's either pointed up or pointed down.

这很重要,因为对脱氧核糖来说,不都是像这样自上而下的,不是对称的自上向下或全部向上的,长链不同是由于,5'碳向上或者向下的指向不同

耶鲁公开课 - 生物医学工程探索课程节选