本发明提供了具有胰高血糖素受体拮抗剂活性或反向激动剂活性的、新颖的式i化合物及其药学上可接受的盐和共晶体。
The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity.
王明伟和同事们通过对48，000多个化合物进行筛选，发现了两个颇有希望的候选结构。 它们能在细胞培养和活体动物模型上模拟胰高血糖素样肽-1的活性。
Ming-Wei Wang and colleagues screened more than 48,000 compounds and identified two promising candidates with the ability to mimic the actions of GLP-1 in cultured cells and in live animals.
以往试图开发口服有效、具有胰高血糖素样肽- 1活性的小分子之努力均未成功，促使科研人员寻找其他途径。
Efforts to develop orally-available small molecules with GLP1-like activity have failed, leading researchers to search for alternatives.
应用推荐