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顺铂通常第一次给药时有效，它有一个主要的缺陷：肿瘤获得耐药性，而且重新开始生长。
While cisplatin is often effective when first given, it has a major drawback: Tumors can become resistant to the drug and start growing again.
Oliver现在研究PIDD基因敲除的肿瘤细胞，看看是否它的缺失阻碍药物耐药性。
Oliver is now studying tumors in which the PIDD gene has been knocked out, to see if its absence hinders drug resistance.
更深入的研究将会阐释恶性胶质瘤中Notch Hedgehog和Wnt通路之间的关系，并寻找使肿瘤产生耐药性的其他信号传导途径，他说。
Further studies will examine the relationship among the Notch, Hedgehog and Wnt pathways in glioblastoma and look for other signaling processes that help tumors become resistant to therapy, he says.
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