...毒的嗜性增强腺病毒载体的转导靶向性,即增加腺病毒载体对靶细胞的感染率,后者可利用肿瘤特异性启动子(tumor specific promoter,TSP)在转录水平对外源基因的调控实现其在肿瘤细胞中的特异表达。
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利用肿瘤特异性启动子 tumor specific promoter
研究肿瘤特异性启动子计算机识别的方法,为基于计算机技术的肿瘤特异性启动子识别研究探索方向。
Studied on the method to recognize tumor peculiar promoter. By means of computational methods, we laid the foundation of gene regulatory system research.
研究结果表明:两种方法都具有较好的识别效果,是可行的利用计算机技术进行肿瘤特异性启动子识别的方法。
The method is checked and test result shown that the recognition method was effective to predict tumor peculiar promoter in the sequence.
转录靶向性利用一些肿瘤过表达某些特定基因,所以使用此基因特异性启动子可以驱动治疗基因达到靶向性治疗目的。
Transcriptional targeting takes advantage of the fact that some cancer cells express a subset of exclusive genes, and USES these cancer-specific promoters to express the desired transgenes.
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