肾清除率常用来表示药物在肾中的排除机制,它是肾小球滤过和肾小管分泌与重吸收的作用结果。
Renal clearance is used to determine renal elimination mechanisms of a drug, which is the result of glomerular filtration, active tubular secretion and reabsorption.
由于转运蛋白的特异性之间存在重叠,药物在肾小管分泌过程中产生的药物的相互作用将是今后临床上值得注意的问题。
Due to overlapping specificities of the transport proteins, drug interactions at the level of tubular secretion is an event that may occur in clinical situation.
应用推荐