目的研究氟桂利嗪(FNZ)、拉莫三嗪(ltg)及两药联合经孕鼠给药，对胎鼠宫内缺血缺氧性脑损害的保护作用。
Objective To investigate the neuroprotective effects of flunarizine (FNZ) and lamotrigine (LTG), and their combination on the hypoxic-ischemic brain damage in fetal rats.
结论急性低压缺氧可引起老龄大鼠大脑皮质和丘脑中et、NO含量明显升高以及大脑皮质血管内皮细胞和神经细胞明显损伤，ET、NO可能参与了缺氧性脑损害的病理过程。
Conclusion It is suggested that, the increase of ET and NO contents of cerebral cortex and thalamus may participate in the pathogenesis of hypoxia brain injury in old rats.
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