之后,经引入手性试剂,双键还原,氢解,水解酯基得到目标产物的合成路线。
The target molecule was synthesized through using chiral reagent, reduction of double bond, hydrogenolysis and hydrolysis of ester group.
方法:以庚二酸单乙酯为原料,经酰氯化、傅克酰化、还原、水解、缩合及氧化反应合成塞曲司特。 结果:塞曲司特的总产率为5 0 .7%。
Methods and results:Through acylation, Friedel Crafts reaction, reduction, hydrolysis, condensation and oxidation, the title compound was prepared with a total yield of 50.7%.
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