近交品系动物的获得,可使原来杂合子的动物增加纯合性(Homozygosity),从而提高基因型的稳定性,获得想要的品系,实验者可以从动物的特定性状中进行选择。
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目的:检测新培育的HL C近交系的基因纯合性。
Aim: To examine the genetic homozygosis of the HLC inbred mouse.
讨论了纯系的纯合性、遗传稳定性以及配合力等方面的特征。
Purity, genetic stability and combining ability of pure lines were discussed.
第8外显子纯合性缺失率为29.3%(12/41),且与患者TNM分期、病理分级及淋巴结转移有关(P<0.05);
The rate of homozygous deletion of Exon8 was 29.3%(12/41), and it was related to the tumor pathological grade, TNM stage and lymph node metastasis (P<0.05).
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