目的探讨纯合子定位法在罕见常染色体隐性遗传病致病基因精确定位中的作用。

Objective To evaluate the role of homozygosity mapping in the fine mapping of the genes responsible for the rare autosomal recessive diseases.

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按照吸烟特点进行亚组分析：在等位基因比较、纯合子比较、隐性遗传模型和显性遗传模型下，都没有发现吸烟与肺癌有显著关联。

In the subgroup analysis stratified by smoking status, no association of smoking was found between 12139c allele and lung cancer under different genetic models.

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