小叶间隔纤维化的特征性改变为轮廓不规则增厚及显著的肺结构改变。
Septal thickening associated with fibrosis is characteristically irregular in contour and associated with distortion of lung architecture.
肌肉活检可见灶性肌纤维坏死，肌纤维横纹消失，小血管壁增厚，个别毛细血管内血栓形成。
Muscular biopsy revealed focal necrotic muscle with loss of muscle fibers, thickened walls of small blood vessels and occasionally thrombosis in capillary.
高倍镜下，系统性硬化症病人真皮中胶原纤维增加使皮肤增厚。免疫荧光检测对硬皮病是无用的。注意：近年来我们往往用系统性硬化症取代名词硬皮病。
At high magnification, the dermis is expanded by dense collagenous fibrosis in a patient with systemic sclerosis. Immunofluorescence is not helpful with scleroderma.
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