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由于妥布霉素固体颗粒在常用滴定溶剂中的溶解度不大，采用常规的卡氏容量法难以快速精确的确定其水含量。
As for the poor solubility of tobramycin crystalline product in working medium used in volumetric Karl Fischer titration, two new methods for the water content determination were investigated.
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